NexGard Spectra was introduced as an expanded version of the original NexGard product. While NexGard primarily targeted fleas and ticks, NexGard Spectra added milbemycin oxime, allowing the medication to protect against heartworm and intestinal worms as well.

The product received authorization in the European Union in 2015 following scientific evaluation by the European Medicines Agency (EMA). Since then, it has become available in many countries across Europe, Asia-Pacific, Latin America, and other regions. [2]

Afoxolaner

Afoxolaner belongs to the isoxazoline class of antiparasitic drugs.

It works by affecting the nervous system of parasites, causing paralysis and death after fleas or ticks attach to the dog.

It is effective against:

• Fleas

• Brown dog ticks

• Black-legged ticks

• Lone star ticks

• Various regional tick species

Milbemycin Oxime

Milbemycin oxime belongs to the macrocyclic lactone family.

It provides protection against internal parasites including:

• Heartworm larvae

• Roundworms

• Hookworms

• Whipworms

In some regions and according to approved labeling, it is also indicated for the treatment or control of certain mites. Approved uses vary by country. [3]

NexGard Spectra is commonly prescribed for:

External Parasites

• Fleas

• Multiple tick species

• Flea infestations

• Tick infestations

Internal Parasites

• Heartworm prevention

• Roundworms

• Hookworms

• Whipworms

Depending on regional regulatory approval, it may also be used as part of treatment for certain mite infestations such as demodectic or sarcoptic mange. Veterinarians follow the approved label for their country. [4]

After the chewable tablet is swallowed:

1. The active ingredients are absorbed into the bloodstream.

2. Fleas and ticks ingest afoxolaner when feeding.

3. Parasites become paralyzed and die.

4. Milbemycin oxime circulates to eliminate susceptible internal parasites and helps prevent heartworm disease by killing larval stages before they mature.

Because it acts systemically, the medication remains effective even after bathing or swimming once it has been absorbed. [5]

NexGard Spectra is available in several weight-based formulations:

Each strength is formulated to deliver the appropriate dose for the dog’s weight. [6]

NexGard Spectra offers several advantages:

• One product protects against multiple parasite types.

• Beef-flavored chewable designed for easy administration.

• Monthly dosing schedule.

• Waterproof after absorption because it works from within the body.

• No topical residue.

• Broad-spectrum parasite coverage in a single tablet.

NexGard Spectra has undergone regulatory evaluation for safety and effectiveness when used according to approved labeling. Like other medicines in the isoxazoline class, it may cause neurological adverse reactions such as tremors or seizures in susceptible dogs, although these events are uncommon. The product should be used under veterinary guidance, especially in dogs with a history of seizures or other neurological disorders. [7]

Most dogs tolerate NexGard Spectra well.

Reported side effects may include:

• Vomiting

• Diarrhea

• Reduced appetite

• Lethargy

• Itching

• Neurological signs (rare)

If serious reactions occur, veterinary care should be sought promptly. [8]

Veterinarians generally recommend:

• Giving one chew every month.

• Selecting the correct strength based on body weight.

• Maintaining monthly dosing for continuous protection.

• Following local recommendations regarding heartworm testing before starting or resuming preventive medication in areas where heartworm is present. [9]

NexGard Spectra is marketed in numerous countries, including parts of:

• Europe

• Australia

• New Zealand

• Southeast Asia

• Japan

• Latin America

• The Middle East

Product labeling, approved indications, and available formulations may differ between countries because of local regulatory requirements. [10]

NexGard Spectra is developed and marketed by Boehringer Ingelheim Animal Health, the animal health division of Boehringer Ingelheim. The company develops vaccines, pharmaceuticals, and parasite-control products for companion animals and livestock. [11]

NexGard Spectra has been approved by veterinary regulatory authorities in numerous countries. In the European Union, it is authorized following assessment by the European Medicines Agency (EMA). In the Philippines, multiple weight-specific formulations are registered with the national regulatory authority as prescription veterinary medicines. [12]

NexGard Spectra is a monthly oral antiparasitic medication for dogs that combines afoxolaner and milbemycin oxime to provide protection against fleas, ticks, heartworm disease, and several intestinal worms. Its broad-spectrum coverage, convenient chewable formulation, and once-monthly dosing have made it a widely used preventive medication in veterinary practice worldwide. When used according to veterinary guidance and local labeling, it offers comprehensive parasite protection with a single monthly treatment.

1. Nexgard Spectra | European Medicines Agency (EMA)

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4. Nexgard Spectra Shop

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7. ネクスガード　スペクトラ® 11.3/22.5/45/90/180 | 製品情報 | ゼノアック［日本全薬工業］

8. When NexGard Spectra Looks “Different”: Why This May Be Dangerous – VET Diagnostix

9. Boehringer Ingelheim introduces NexGard SPECTRA® for dogs in India

10. Product information

11. Marketing Authorisation Number – NEXGARD SPECTRA (all pack sizes) Great Britain only

12. Nexgard Spectra | European Medicines Agency (EMA)