Neurogen-E® is a widely recognized brand in the Philippines known for its high-dose Vitamin B-complex and Vitamin E formulation. Marketed primarily by United Laboratories (Unilab), the product is positioned as a medicinal vitamin intended to support nerve health and address conditions associated with deficiencies in vitamins B1, B6, B12, and E. It is available over-the-counter (OTC) through major drugstores and online pharmacies across the country.

Unlike standard daily multivitamins, Neurogen-E contains significantly higher doses of specific B-vitamins. Consequently, it is generally not recommended for use as an ordinary nutritional supplement without considering total intake, particularly for those taking other B-vitamin products.

The Philippine FDA classifies Neurogen-E as a Vitamin B-Complex + Vitamin E tablet. Regulatory records identify Amherst Laboratories Inc. as the manufacturer and UNILAB, Inc. as the trader and distributor 1.

Neurogen-E is part of the consumer health portfolio of United Laboratories, Inc. (Unilab), one of the largest pharmaceutical companies in the Philippines. While Unilab is the brand owner and primary marketer facing consumers, regulatory documents indicate that manufacturing may be conducted by associated entities such as Amherst Laboratories Inc. MIMS lists UNILAB, Inc. as both the manufacturer and distributor within the Philippine market 1.

The central positioning of Neurogen-E is nerve care. Unilab markets the product to help maintain healthy nerves and alleviate symptoms commonly described by Filipino consumers using local terms:

• Tusok-tusok: Pins-and-needles or pricking sensations.
• Ngalay: Numbness, tingling, or limb fatigue.
• Manhid: General numbness or reduced sensation.
• Muscle pain associated with vitamin deficiency.
• Abnormal touch sensations, such as burning or prickling.

Official prescribing information also notes responsiveness in conditions like polyneuropathy, diabetic neuropathy, neuralgia, neuritis, Wernicke’s disease, beriberi, sideroblastic anemia, and pernicious anemia. However, these are serious medical conditions; the presence of Neurogen-E in this context does not imply that self-medication is appropriate without professional guidance 1.

The standard Philippine formulation combines four key nutrients at therapeutic doses:

These quantities are derived from current Unilab product information 1. The high concentration of B12 (1,000 mcg) and B1 (300 mg) serves as a primary marketing differentiator, with the company claiming the formulation provides 5× more vitamin B12 and 3× more vitamin B1 compared to major OTC B-complex brands, alongside added Vitamin E 1. These comparisons reflect brand positioning rather than a universal clinical conclusion of superiority over all other supplements.

Distinction from Regular B-Complex

While conventional B-complex supplements provide modest amounts of various B vitamins for general nutritional support, Neurogen-E concentrates on B1, B6, and B12 at comparatively high doses specifically targeted at nerve health. It is conceptually positioned between ordinary multivitamins and prescription treatments for underlying neurologic diseases.

The official direction for adults is one tablet orally once daily, or according to a physician’s instructions 1. There is no specific required time of day for administration. If a dose is missed, users are advised to take the next scheduled dose rather than doubling up to compensate 1.

Although classified as OTC, Neurogen-E contains potent ingredients that require caution.

Vitamin B6 Considerations

Each tablet contains 100 mg of Vitamin B6. Long-term exposure to high amounts of pyridoxine can itself cause peripheral neuropathy. Users should avoid stacking Neurogen-E with other high-B6 supplements to prevent excessive total intake.

Drug Interactions

• Anticoagulants: Vitamin E may enhance the blood-thinning effects of anticoagulants like warfarin. Caution is advised for individuals with coagulation problems 23.
• Seizure Medications: High-dose Vitamin B6 may reduce blood levels of phenobarbital or phenytoin. Administration of these drugs and Neurogen-E should be separated by at least two hours 2.

Contraindications

Cyanocobalamin (Vitamin B12) is contraindicated in individuals with hypersensitivity to cobalt. It should not be used in patients with early Leber’s disease due to reports of optic-nerve deterioration 1.

The manufacturer recommends Neurogen-E for adults aged 18 years and older. For children under 18, consultation with a pediatrician is required. Pregnant women and breastfeeding mothers should consult a physician or OB-GYN before use, as nutrients can be excreted into breast milk 1.

To maintain product integrity, store Neurogen-E:

• Out of the sight and reach of children.
• At temperatures no higher than 30°C.
• Protected from light 1.

Neurogen-E is widely distributed across the Philippines in leading drugstores (such as Watsons) and online pharmacies. Prices vary depending on the retailer, pack size, and ongoing promotions. Retail listings show individual tablets and multi-tablet packs, but prices are subject to change and are not fixed by the brand 3.

Beyond the Philippines, Neurogen-E has a presence in Singapore. The National Drug Formulary lists NEUROGEN-E TABLET, manufactured by United Laboratories Inc. – Philippines, containing cyanocobalamin, pyridoxine, thiamine, and vitamin E. In Singapore, it is classified as a pharmacy-only medicine, reflecting potential differences in regulatory classification between countries .

According to the Philippine FDA database record:

• Registration Number: DR-XY31242
• Issuance Date: July 8, 2022
• Expiry Date: May 19, 2028
• Classification: OTC Vitamin
• Manufacturer: Amherst Laboratories Inc.
• Trader: UNILAB, Inc.

This distinction highlights that while Unilab is the consumer-facing brand entity, specific regulatory records identify the manufacturing facility.

1. Neurogen E | Vitamins & Supplement for Nerve Health | Unilab
2. Neurogen-E | Drug Interactions | MIMS Philippines
3. NEUROGEN, Neurogen E Vitamin B – Complex + Vitamin E 8 Tablets | Watsons Philippines